Editorial Comment to the January 2014 Issue of IMARS Highlights

On behalf of IMARS president, Prof. Teruo Miyazawa, the editorial office expresses the greetings of the new year, 2014.

This New Year special issue includes a mini review written by Prof. Shing Hwa Liu,entitled “Advanced glycation end products and osteoarthritis”.

Osteoarthritis is one of the most prevalent and chronic musculoskeletal diseases, which is predominantly caused by aging and glycative stress. Recent studies highlighted that osteoarthritis is associated with abnormal accumulation of advanced glycation end products (AGEs) in articular cartilage, leading to the stiffness and brittleness of cartilage. This review article summarizes the impact of the accumulation of AGEs in human articular cartilage in the development of osteoarthritis and the future possibility of therapeutic approaches targeting cartilage AGEs.

The second special article entitled “Novel Mass Spectrometric Tools for the Search of New Maillard Products and AGEs” is written by Prof. Monika Pischetsrieder, a Contributing Editors of the IMARS Highlights, at University of Erlangen-Nuremberg, Germany. In this review article, she introduced two complementary mass spectrometry methods, MALDI-TOF-MS and UHPLC-MSMS, which have been developed to search for new structures of food-derived Maillard products. These novel dietary AGEs will open a new avenue to understand the nutritional and toxicological effects of glycation in food.

The third article is a conference report of the Glyoxalase centennial meeting written by Prof. Masanari Itokawa at Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. This memorial meeting was organized by Profs. Naila Rabbani andPaul Thornalley, who are well-established glyoxalase researchers, and was held on November 27-29 in University of Warwick, UK, last year. I am delighted that this article can remind you of “History of 100 Years of Glyoxalase Research”.

The IMARS Highlights editors look forward to your contribution to the field of food and medical glycation researches as always. Please contact us.

Reiko Inagi, PhD

Division of Nephrology and Endocrinology
University of Tokyo, School of Medicine

email: [email protected]

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