Editorial Comment to the July 2013 Issue of IMARS Highlights

This issue published two interesting mini reviews written by Profs. Christina Piperi and Melinda T Coughlan. Prof. Christina Piperi from University of Athens Medical School, Greece, highlighted the link between glycation and endoplasmic reticulum (ER) stress, which is an important pathophysiology in various diseases. She summarized the novel effect of AGEs in induction of ER stress and the subsequent cell apoptosis in the endothelial cells. AGEs contribute to the enhancement of oxidative stress, inflammation, and metabolic abnormalities as well as ER stress, and thereby are intricately associated with the progression of AGE-related diseases. Prof. Melinda T Coughlan at Monash University, Australia, focused on the effect of dietary prebiotic supplementation for reduction of glycative stress. Prebiotics, which selectively stimulate the growth of beneficial bacteria in the human colon, might offer protection against AGE-induced pathology by the maintenance of gut barrier function and the reduction of oxidative stress, inflammation and insulin resistance.

This issue also includes the memorial articles by Dr. Keiichi Kimura at Meiji University, a winner of Young Investigator Award of the 22nd Japanese Maillard Reaction Society (JMARS) meeting held on December 21-22 in Tokyo last year. He demonstrated the effect of riboflavin as a novel glycation inhibitor, which decomposes the Amadori compound.

The IMARS Highlights editors look forward to submission of your articles related to glycation in the field of food and medical sciences as always. Please contact us!

Reiko Inagi, PhD
Division of Nephrology and Endocrinology
University of Tokyo, School of Medicine

email: [email protected]

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