Editorial Comment to the September 2017 Issue of IMARS Highlights

IMARS Highlights Vol 12-5_Sept2017

Editorial comments

In this issue, we specially invited two internationally active researchers in the field of medical glycation research: Prof. Mitsuhiro Miyashita at Project for Schizophrenia Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan and Prof. Naila Rabbani at Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK.

Prof. Mitsuhiro Miyashita and his group are working on schizophrenia, which is a mental disorder associated with the symptoms including abnormal social behavior, unclear thinking, or unstable emotions. In this article, they focused on the link between schizophrenia and glycation, especially receptor for advanced glycation end-products (RAGE) and summarized the evidence showing that the levels of serums soluble RAGE and endogenous secretory RAGE are decreased in the patients with schizophrenia. RAGE may be a new target for diagnosis and therapy for schizophrenia.

Prof. Naila Rabbani and her colleagues summarized the beneficial effect of glyoxalase system, which is a well-conserved defense mechanism against glycative stress: glyoxalase system detoxifies AGE precursors such as reactive dicarbonyl compounds. Importantly, they also summarized the updated information about the clinical impact of glyoxalase system activator. Such glyoxalase system activator may be a new hope to prevent the development/progression of various diseases related to glycation, including diabetes, cardiovascular disease, diabetic kidney disease, etc.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, PhD

Division of Chronic Kidney Disease Pathophysiology
The University of Tokyo Graduate School of Medicine
email: [email protected]

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