Archive for the ‘ IMARS News ’ Category

Editorial Comment to the March 2017 Issue of IMARS Highlights

IMARS march

Editorial comments

In this issue, we selected two articles highlighted the link between stress signal and glycation.

The first article written by Dr. Christos Adamopoulos and Prof. Christina Piperi, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Greece, summarized that high-AGE content diet causes endoplasmic reticulum (ER) dysfunction, referred to as ER stress, in brain, kidney, liver and pancreas, and thereby induces stress signal, unfolded protein response (UPR). The UPR pathway is known to regulate not only protein homeostasis, but also glucose and lipid metabolism. Thus, dietary AGEs may contribute to development and progression of metabolic diseases via the UPR activation that alters metabolic status in metabolic organs.

The second article written by Prof. Chih-Kang Chiang, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taiwan, demonstrated the impact of pathogenic effect of AGEs on mesangial cell injury, which is one of the major phenotypic changes of diabetic nephropathy. AGEs induce ER stress in mesangial cells, and subsequently decrease mesangial cell viability associated with induction of apoptosis. Importantly, such AGEs-ER stress-mesangial cell apoptosis axis is regulated by autophagy. These findings suggest that the AGEs-induced autophagy mediated by ER stress may be a therapeutic target for prevention of mesangial cell damage and subsequent progression of diabetic nephropathy.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]

Editorial Comment to the January 2017 Issue of IMARS Highlights

IMARS HighlightEditorial comments

IMARS committees would like to celebrate a very happy and successful 2017 to all the members of IMARS. Our society will keep moving forward and we expect your continuous contribution to the IMARS Highlights. I, as an editor of the IMARS Highlights, promise that this on-line journal will provide you useful and exciting information about glycation research in different fields, from food science to medicine, to enjoy international and different-field exchange, and enhance collaboration.

In the New Year issue of this year, we invited Prof. Yuri Nomi at Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. Her article, entitled “Useful and accurate method for Simultaneous Quantitation of Advanced Glycation End Products by Liquid Chromatography-Tandem Mass Spectrometry without Ion-Pair Reagents and Derivatization”, summarizes a novel simple and sensitive method for the simultaneous determination of various AGEs by LC-MS/MS. The LC-MS/MS method revealed that materials, processing condition, and protein content clearly affects the levels of free AGEs in food.

The second article, entitled “The effect of molecular crowding on Maillard reaction”, was written by Dr. Edoardo Capuano at Wageningen University, Wageningen, the Netherlands. This article focuses on the link between molecular crowding and Maillard reaction in the field of food science.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences. 

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology
The University of Tokyo Graduate School of Medicine

 

Season’s Greetings

untitledDear All IMARS members,

Happy Holidays and a Happy New Year from the team at IMARS Highlights.

Thank you for your great contributions to the IMARS Highlights.

 IMARS Highlights, Editor

Reiko Inagi, Ph.D.

Division of Chronic Kidney Disease Pathophysiology,

The University of Tokyo Graduate School of Medicine.

 

Editorial Comment to the November 2016 Issue of IMARS Highlights

IMARS2016-3

Editorial Comment

In this issue, we publish two articles of the field of food science of glycation research.

The review article written by Prof. Frédéric J Tessier, Lille Inflammation Research International Center, Lille University, France, focuses on the benefit of butter consumption in healthy life style. Over intake of saturated fatty acids, but not unsaturated fatty acids, is a risk factor of cardiovascular disease.  However, unsaturated fatty acids are structurally unstable and are processed to toxic compounds under the certain conditions, indicating the beneficial properties of saturated fatty acids rather than unsaturated fatty acids in healthy food intake.
The second updated article written by Dr. Jianlei Liu and Prof. Hao Jing, China Agricultural University, China, demonstrated the impact of glycation on heat-induced protein aggregation. The thermal denaturation of food proteins may be lowered by glycation.

I deeply thank their great contributions to the IMARS Highlights.The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology
The University of Tokyo Graduate School of Medicine

 

email: [email protected]

Editorial Comment to the September 2016 Issue of IMARS Highlights

Editorial commentsIMARS2016-3

This issue publishes two interesting review articles in the field of medical glycation research.

The first review article written by Prof. Alejandro Gugliucci, Touro University California, USA, focuses on the pathogenic roles of AGE formation by exogenous fructose, especially in tissues where its concentrations are high, such as intestines and liver. This article gives you a hint of establishment of glycation research regarding fructose.

The second review article written by Prof. Xianhui Qin, Nanfang Hospital, Southern Medical University, China, demonstrates that the folic acid therapy should be considered for the prevention of cardiovascular disease in patients with chronic kidney disease. From the point of view that chronic kidney disease is a risk factor of development of cardiovascular disease, the benefit of folic acid to cardiovascular disease is important to ameliorate the poor prognosis of CKD patients.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, PhD
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine

email: [email protected]