This issue publishes the updated evidence regarding the link between advanced glycation endproducts (AGEs) and longevity, entitled “Drug repositioning to target aging and age-related diseases” by Dr. Mahesh J. Kulkarni at Division of Biochemical Sciences, CSIR-National Chemical Laboratory, India. Recently they found that rifampicin (RIF), which was developed initially as antibiotics, affects longevity by modifying transcription of genes and glycative stress. At the post-translational level, RIF reduces AGE formation (glycation) on major cellular proteins that control metabolism and support musculature. At the transcriptional level, RIF activates genes involved in aging, proteolysis, cell cycle and cellular detoxification. These multi-dimensional effects of RIF indicate the possibility of RIF as a drug for longevity and healthy super-aging society.
We also publish a summary of dicarbonyl stress, written by Prof. Naila Rabbani at Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK. Dicarbonyl stress is the abnormal accumulation of α-oxoaldehyde metabolites, including methylglyoxal, glyoxal, and 3-deoxyglucosone, all of which posttranslationally modify protein and DNA (glycation), and thereby contribute to cell and tissue dysfunction in aging and disease. This review highlights the pathogenesis of dicarbony stress, namely glycative stress, and the importance of glyoxalase as a defensive mechanism against dicarbony stress.
Please also pay attention to the 12th International Symposium on the Maillard Reaction (ISMR 12, http://www.imars.umin.jp/) meeting to be held in Tokyo on September 1-4. Members of the local committee and the international committee are devoting themselves to hold an outstanding meeting for participants and attendees. This will be a very important and exciting year for Maillard researchers, and please do not miss this rare opportunity for global liaison and fruitful collaboration with other colleagues of the society.
Reiko Inagi, PhD
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]