Editorial Comment to the July 2017 Issue of IMARS Highlights

IMARS Highlights Vol 12-4_July2017

Editorial comments

This issue specially invited two internationally active researchers in the field of food glycation research, Prof. Monika Pischetsrieder at Friedrich-Alexander Universität Erlangen-Nürnberg, Germany and Prof. Norma Frizzell at University of South Carolina School of Medicine, USA.

Prof. Monika Pischetsrieder focuses on the technical impact of proteomics to evaluate non-enzymatic posttranslational modifications of proteins by Maillard reaction in processed food and summarizes future perspective of achievement of qualitative and quantitative non-targeted proteomic analysis. Such technical progress will give us new insight to understand protein damage by Maillard reaction during food processing.

Prof. Norma Frizzell and her colleagues highlight the pathophysiological effect of fumarate-induced succination in a variety of conditions associated with mitochondrial dysfunction, leading to induction of mitochondrial stress as well as endoplasmic reticulum stress. They update the mechanism how various kinds of succinated proteins induce different pathophysiological effects in different cells or organs.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, PhD

Division of Chronic Kidney Disease Pathophysiology
The University of Tokyo Graduate School of Medicine
email: [email protected]

Editorial Comment to the May 2017 Issue of IMARS Highlights

IMARS march

Editorial comments

This special issue includes two articles written by the winners of Young Investigator Award of the 26th Japanese Maillard Reaction Society (JMARS) meeting, Drs. Kyoko Noda (Oral) and Ai Harashima (Poster). The JAMRS annual meeting was held on November 11-12, 2016 at International Congress Center Epochal Tsukuba, Tsukuba, Ibaraki.

Dr. Kyoko Noda at Department of Nutrition and Food Science, Ochanomizu University, Tokyo, received the best oral presentation award on her food science research on “Novel Maillard Yellowish Pigments Having Pyrrolothiazole or Pyrrolooxazole Skeleton”. She identified three novel yellowish Maillard pigments having pyrrolothiazole or pyrrolooxazole skeleton, which may be specific in the Maillard reaction

Dr. Ai Harashima at Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, got the best poster presentation award on her medical science research on “Perception of pathogenic bacteria by pattern recognition receptor RAGE in the frontline”. She demonstrated that the critical role of RAGE in the early innate immune responses to invading pathogens by sensing microorganism.

These young and active researchers will open a new avenue to advance the science for Maillard reaction. I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

 

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]

Editorial Comment to the March 2017 Issue of IMARS Highlights

IMARS march

Editorial comments

In this issue, we selected two articles highlighted the link between stress signal and glycation.

The first article written by Dr. Christos Adamopoulos and Prof. Christina Piperi, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Greece, summarized that high-AGE content diet causes endoplasmic reticulum (ER) dysfunction, referred to as ER stress, in brain, kidney, liver and pancreas, and thereby induces stress signal, unfolded protein response (UPR). The UPR pathway is known to regulate not only protein homeostasis, but also glucose and lipid metabolism. Thus, dietary AGEs may contribute to development and progression of metabolic diseases via the UPR activation that alters metabolic status in metabolic organs.

The second article written by Prof. Chih-Kang Chiang, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taiwan, demonstrated the impact of pathogenic effect of AGEs on mesangial cell injury, which is one of the major phenotypic changes of diabetic nephropathy. AGEs induce ER stress in mesangial cells, and subsequently decrease mesangial cell viability associated with induction of apoptosis. Importantly, such AGEs-ER stress-mesangial cell apoptosis axis is regulated by autophagy. These findings suggest that the AGEs-induced autophagy mediated by ER stress may be a therapeutic target for prevention of mesangial cell damage and subsequent progression of diabetic nephropathy.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences.

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]

Editorial Comment to the January 2017 Issue of IMARS Highlights

IMARS HighlightEditorial comments

IMARS committees would like to celebrate a very happy and successful 2017 to all the members of IMARS. Our society will keep moving forward and we expect your continuous contribution to the IMARS Highlights. I, as an editor of the IMARS Highlights, promise that this on-line journal will provide you useful and exciting information about glycation research in different fields, from food science to medicine, to enjoy international and different-field exchange, and enhance collaboration.

In the New Year issue of this year, we invited Prof. Yuri Nomi at Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. Her article, entitled “Useful and accurate method for Simultaneous Quantitation of Advanced Glycation End Products by Liquid Chromatography-Tandem Mass Spectrometry without Ion-Pair Reagents and Derivatization”, summarizes a novel simple and sensitive method for the simultaneous determination of various AGEs by LC-MS/MS. The LC-MS/MS method revealed that materials, processing condition, and protein content clearly affects the levels of free AGEs in food.

The second article, entitled “The effect of molecular crowding on Maillard reaction”, was written by Dr. Edoardo Capuano at Wageningen University, Wageningen, the Netherlands. This article focuses on the link between molecular crowding and Maillard reaction in the field of food science.

I deeply thank their great contributions to the IMARS Highlights. The IMARS Highlights editors always look forward to submission of your articles, comments to any kinds of issues published in IMARS Highlights and other glycation-related issues in the field of food and medical sciences. 

Reiko Inagi, Ph.D.
Division of Chronic Kidney Disease Pathophysiology
The University of Tokyo Graduate School of Medicine

 

Season’s Greetings

untitledDear All IMARS members,

Happy Holidays and a Happy New Year from the team at IMARS Highlights.

Thank you for your great contributions to the IMARS Highlights.

 IMARS Highlights, Editor

Reiko Inagi, Ph.D.

Division of Chronic Kidney Disease Pathophysiology,

The University of Tokyo Graduate School of Medicine.