The May issue (2015) publishes a comment on the AGE research, entitled “AGE: the vital point to healthy life in the aging society”, written by Prof. Masaomi Nangaku at the University of Tokyo Graduate School of Medicine, Tokyo, Japan. In Japan, the super-aging society associated with kidney aging exacerbates development and progression of chronic kidney disease (CKD): one out of 8 adults suffers from CKD and the number of CKD patients is rapidly increasing. Accumulating evidence emphasize that the link between aging and glycative stress, namely accumulation of advanced glycation endproducts (AGEs) and subsequent induction of stress signals to glycative stress, is an important point to disturb the kidney homeostasis and super-aging society. It strongly suggests that AGE research remains one of the most exciting areas in medicine, especially translational medicine contributes to healthy and active super-aging society.
We also publishes a mini review, entitled “Poor bone quality in diabetes”, written by Prof. Mitsuru Saito at Jikei University School of Medicine, Japan. This review summarizes the up-to-date mechanisms how bone cell homeostasis is affected by AGEs and the impact of the AGE formation inhibitors to reduce fracture risk in diabetic patients. Diabetic complications, including fracture, are closely associated with the decrease in quality of health and poor prognosis. This review also emphasizes the importance of AGE research on healthy and active super-aging society.
Please also pay attention to the 12th International Symposium on the Maillard Reaction (ISMR 12, http://www.imars.umin.jp/) meeting to be held in Tokyo on September 1-4. Members of the local committee and the international committee are devoting themselves to hold an outstanding meeting for participants and attendees. This will be a very important and exciting year for Maillard researchers, and please do not miss this rare opportunity for global liaison and fruitful collaboration with other colleagues of the society.
Reiko Inagi, PhD
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine