In this issue, we invited Dr. So Motoyoshi at Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. It is known that advanced glycation end-products (AGEs) bind to the receptor for AGE (RAGE) and induce inflammation. He and Prof. Yamamoto’s group recently demonstrated that an increase in cyclic adenosine monophosphate (cAMP) suppresses inflammation via RAGE both in vivo and in vitro. This article emphasizes not only the pathophysiological importance of RAGE-AGE pathway in RAGE-related diseases but also a possibility of novel approaches based on RAGE to these diseases.
We also published the Young Investigation Award abstract of Japanese Society of Maillard Reaction (JMARS) written by Dr. Jun-ichi Shirakawa, who received the Young Investigator Award of the 24nd JMARS meeting held on November 7-8 in Kumamoto last year, at School of Agriculture, Tokai University. He and Prof. Nagai’s group reported the impact of AGE measurement on diagnosis of metabolic disorders.
Please also pay attention to the 12th International Symposium on the Maillard Reaction (ISMR 12) meeting to be held in Tokyo on September 1-4. Members of the local committee and the international committee are devoting themselves to hold an outstanding meeting for participants and attendees. This will be a very important and exciting year for Maillard researchers, and please do not miss this rare opportunity for global liaison and fruitful collaboration with other colleagues of the society.
Reiko Inagi, PhD
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]