Editorial Comment to the March 2015 Issue of IMARS Highlights

2015Editorial comments

In this issue, we invited Dr. So Motoyoshi at Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan. It is known that advanced glycation end-products (AGEs) bind to the receptor for AGE (RAGE) and induce inflammation. He and Prof. Yamamoto’s group recently demonstrated that an increase in cyclic adenosine monophosphate (cAMP) suppresses inflammation via RAGE both in vivo and in vitro. This article emphasizes not only the pathophysiological importance of RAGE-AGE pathway in RAGE-related diseases but also a possibility of novel approaches based on RAGE to these diseases.    

We also published the Young Investigation Award abstract of Japanese Society of Maillard Reaction (JMARS) written by Dr. Jun-ichi Shirakawa, who received the Young Investigator Award of the 24nd JMARS meeting held on November 7-8 in Kumamoto last year, at School of Agriculture, Tokai University. He and Prof. Nagai’s group reported the impact of AGE measurement on diagnosis of metabolic disorders.

Please also pay attention to the 12th International Symposium on the Maillard Reaction (ISMR 12) meeting to be held in Tokyo on September 1-4. Members of the local committee and the international committee are devoting themselves to hold an outstanding meeting for participants and attendees. This will be a very important and exciting year for Maillard researchers, and please do not miss this rare opportunity for global liaison and fruitful collaboration with other colleagues of the society.

 

Reiko Inagi, PhD

 

Division of Chronic Kidney Disease Pathophysiology,

The University of Tokyo Graduate School of Medicine

email: [email protected]

 

 

 

 

Editorial Comment to the January 2015 Issue of IMARS Highlights

2015Editorial comments

On behalf of the IMARS president, Prof. Miyazawa, we wish all of Maillard reaction researchers a very happy and successful 2015. As we announced previously, we will have the 12th International Symposium on the Maillard Reaction (ISMR 12) meeting in Tokyo on September 1-4. Members of the local committee and the international committee are devoting themselves to hold an outstanding meeting for participants and attendees. This will be a very important and exciting year for Maillard researchers, and please do not miss this rare opportunity for global liaison and fruitful collaboration with other colleagues of the society.

              As a special mini review of the New Year issue, we invited Prof. Shinji Kume at Shiga University of Medical Science, Shiga, Japan, to summarize the updated information of autophagy in diabetes and kidney disease. Autophagy is an important intracellular catabolic pathway to degrade proteins or damaged organelles and recycle amino acids. Thus, autophagy can maintain the protein homeostasis (proteostasis). Under hyperglycemic conditions, the catabolic activity of autophagic pathway is deranged and contributes to maladaptation to diabetic stress via the loss of protein quality, especially accumulation of unfavorable proteins/organelles. This review highlights the novel pathophysiological significance of glycation on protein homeostasis via autophagy.   

We also published the Young Investigation Award abstract of Japanese Society of Maillard Reaction (JMARS) written by Dr. Sachie Kato, who received the Young Investigator Award of the 24nd JMARS meeting held on November 7-8 in Kumamoto last year, at Department of Agricultural Chemistry, Meiji University.

The IMARS Highlights editors look forward to your contribution to the field of food and medical glycation researches as always. Please contact us.

 

Reiko Inagi, PhD

 

Division of Chronic Kidney Disease Pathophysiology,

The University of Tokyo Graduate School of Medicine

email: [email protected]

 

 

 

 

Editorial Comment to the September 2014 Issue of IMARS Highlights

 

Editorial comments

This issue publishes three interesting articles. The first article written by Prof. Alejandro Gugliucci at Touro University-California, USA, summarizes updated pathophysiology of glycation signals (RAGE-AGEs) in kidney disease, especially chronic kidney disease (CKD). The number of CKD patients is dramatically increasing in all developed counties, thus this article will help the readers to understand the pathophysiological contribution of glycation (or glycative stress) in kidney homeostasis.

The second article written by Prof. Masako Toda at Paul-Ehrlich-Institute, Germany, highlights the impact of glycation of a food allergen against immune response. She summarizes the mechanism how the glycation of ovalbumin, a major egg white allergen, alters the T cell activation as well as antigen presenting pathway.

The third article written by Katsumasa Iijima at Nippi Research Institute of Biomatrix, Japan, summarizes that glyoxal derived AGEs at arginine residues, such as N-carboxymethylarginine (CMA) and hydroimidazolones (G-Hs), cross-convert with each other in various conditions, indicating the complicated effect of glycation (AGE formation and structure) in arginine against protein homeostasis.

  The IMARS Highlights editors look forward to your contribution to the field of food and medical glycation researches as always. Please contact us.

Reiko Inagi, PhD

Division of Chronic Kidney Disease Pathophysiology,

The University of Tokyo Graduate School of Medicine

email: [email protected]

 

Next ISMR

12th International Symposium on the Maillard Reaction

1st. Iberoamerican Symposium on AGEs

1st. Iberoamerican Symposium on AGEs

The only event specialized in Advanced Glycation End Products in Latin America will take place from 1 to 3 October 2014 in beautiful and historical, Guanajuato, Mexico.

Spearheaded by founding members of IMARS, the international Symposium is organized by researchers at the University of Guanajuato, Universidad de Chile, Touro University (California) and Mount Sinai (New York).

Mark the date and update your knowledge of nutrition!

The modernization of our society has brought profound changes in lifestyle and also a progressive increase in chronic diseases such as obesity, metabolic syndrome and diabetes. The frequency of these diseases has reached almost epidemic levels and there is urgency to find solutions that can stop these processes.

Diet is undoubtedly an important component of modern lifestyle that singly or in combination may play an important role in the initiation of these diseases. Recent research suggests a strong relationship between blood levels of so-called Advanced Glycation End Products or AGEs and these diseases. AGEs are a highly heterogeneous group of compounds that can be generated within the body itself or ingested preformed in foods depending mainly on how to cook.

These diseases are highly prevalent in Mexico and other Spanish-speaking countries and it is time to start discussing in detail potential solutions to this problem in the region. The role of AGEs in the generation of diabetes and other chronic diseases will be the focus of discussion in this symposium. The purpose is to bring together researchers in this issue of the Latin American world and try to reach consensus on what is really established and new research ideas should be developed. We hope that this symposium is just the beginning of regular meetings of this group of Latin American researchers to discuss progress and then spread the message of IMARS in Spanish for the benefit of medical doctors, researchers, nutritionists and the patients in the area.


Please visit the website below:

http://www.agesenlasalud.com/