This issue publishes three interesting articles. The first article written by Prof. Alejandro Gugliucci at Touro University-California, USA, summarizes updated pathophysiology of glycation signals (RAGE-AGEs) in kidney disease, especially chronic kidney disease (CKD). The number of CKD patients is dramatically increasing in all developed counties, thus this article will help the readers to understand the pathophysiological contribution of glycation (or glycative stress) in kidney homeostasis.
The second article written by Prof. Masako Toda at Paul-Ehrlich-Institute, Germany, highlights the impact of glycation of a food allergen against immune response. She summarizes the mechanism how the glycation of ovalbumin, a major egg white allergen, alters the T cell activation as well as antigen presenting pathway.
The third article written by Katsumasa Iijima at Nippi Research Institute of Biomatrix, Japan, summarizes that glyoxal derived AGEs at arginine residues, such as N-carboxymethylarginine (CMA) and hydroimidazolones (G-Hs), cross-convert with each other in various conditions, indicating the complicated effect of glycation (AGE formation and structure) in arginine against protein homeostasis.
The IMARS Highlights editors look forward to your contribution to the field of food and medical glycation researches as always. Please contact us.
Reiko Inagi, PhD
Division of Chronic Kidney Disease Pathophysiology,
The University of Tokyo Graduate School of Medicine
email: [email protected]